A 83-01 _ 53002ES Recombinant Protein 5 pg/μL unmodified dsRNA standard

5 pg/μL unmodified dsRNA standard at three volume ratios (1:1

Bioorg Chem

Ser46-Ile113

but trimming of the Ntermini enhances its activity

5% trehalose

A 83-01 _ 53002ES Recombinant Protein 5 pg/μL unmodified dsRNA standardA 83 01 is a potent inhibitor of TGF type I receptor ALK5 (IC50: 12 nM) ALK4 ((IC50: 45 nM) ALK7 (IC50: 7. 5 nM) kinase, A 83 01 has a strong inhibitory effect on ALK5 and can inhibit phosphorylation of Smad2 3 and TGF induced growth. A 83 01 has little or no effect on bone morphogenetic protein type I receptors, p38 mitogen activated protein kinases, or extracellular regulatory kinases. At the same time, A 83 01 inhibits TGF induced epithelial