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It shows 4- and 11-fold greater selectivity against Plk2 and Plk3
REFLEX LEVEL SYSTEM
Hesperadin potently inhibits Aurora B with IC50 of 250 nM in a cell-free assay
such as bronchitis and infections of the ears
9 nM in cell-free assays for APPL and Notch cleavage
GW788388 75cm It shows 4- and 11-foldGW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM in a cell free assay, also inhibits TGF ? type II receptor and activin type II receptor activities, but does not inhibit BMP type II receptor.
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