Caged Sun, Extraplanar Lens, etc.) + at least six lands = infinite mana Palinchron + Phantasmal Image = infinite mana High Market + Nim Deathmantle + Palinchron /Diamond Valley = infinite mana, infinite life, and infinite gravestorm Contagion Engine + Filigree Sages + Magistrate's Scepter = infinite turns Knowledge Pool + Teferi, Mage of Zhalfir = lockdown (opponents can't cast spells from hand) Arcane Laboratory + Erayo, Soratami Ascendant flipped = opponents can't cast spells March of the Machines/Karn's Touch/Animate Artifact/Tezzeret the Seeker /Toymaker + Voltaic Construct + any artifact with CMC one or more that taps for more than 2 = infinite mana Academy Researchers + Fool's Demise + sac outlet = infinite sacrifices Umbral Mantle/Lightning Greaves/Shuko + Cephalid Aristocrat/Cephalid Illusionist = infinite self-mill Tunnel Vision + Vendilion Clique /Spell Crumple/Hinder/Proteus Staff + a creature owned by an opponent + know the top card of your opponent's library and they scry it away = mill target player's library Homarid Spawning Bed + Nim Deathmantle + Palinchron = infinite tokens Isochron Scepter with Mystical Tutor + Beacon of Tomorrows = infinite turns Amulet of Vigor + Patron of the Moon + Storm Cauldron = infinite mana/landfall Amulet of Vigor + Ghost Town + Patron of the Moon = infinite landfall during opponent's turns Amulet of Vigor + Meloku the Clouded Mirror + Patron of the Moon + 2 land = infinite tokens/landfall Krark-Clan Ironworks + March of the Machines + Salvaging Station + any 1 drop non-creature artifact = infinite colorless mana

Some decks will still prefer the 1-drop, but this has combat stats, sacs artifacts, and surveils instead of scrying, which is all major upsides on a free sac outlet
Luffy should need no introduction, as the protagonist of One Piece and the leader of the Straw Hat Pirates
Cards like Tandem Lookout and Keen Sense allow you to draw cards when Niv-Mizzet deals damage, allowing you to draw more cards, then deal more damage, and then draw more cards until the opponent has no life
While this doesnt sound like much, it can be a real difference-maker if youre going to fall just short of a KO