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Look at the following example

Since most of you probably don't design Magic cards and this may not mean anything to you, let me use a Hollywood metaphor

Those 12,800 words I ended up having to write about Extended were also part of my list

Filling your hand and graveyard with the same number of cards could just set you ahead further than your opponents have the time to catch up with

It is rather on the all in side, not only because it hits your total resources pretty hard but because of the style of deck where Smallpox is optimal - if all your cards are cheap (or at least the ones you plan to cast) then you are less likely to have that much late game legs