The cards you can turn into creatures have to cost more than four mana, and Bello costs three, so you need Bello to stick around for a bit and you have to have several enchantments in play to really keep the pressure up
If you do, search your library for a creature or basic land card, reveal it, put it into your hand, then shuffle
The worst case is that Universes Beyond really does cause some long-time players to quit the game, and while Universes Beyond sells well, it's mostly a novelty item that fans of other IPs buy as a joke or to fill our their memorabilia collection, but few actually starting playing the game of Magic , which would be fairly disastrous
Youre generally not going to have Spider-Man and villains in the same Commander deck, so once we committed to lots of characters, we knew that meant you wouldnt be putting them all in the same deck, and so that made for a great opportunity to make each villain more distinct and emphasize their different goals and methods in the card designs
Beyond that though, Enchantress has a huge variety of ways to stop anything our opponents are doing