binding of isaac base card game Maestro Media: The Isaac: Four Souls (2nd Edition) - Strategy Game, Officially Licensed, Ages 13+, 1-4+ Players, 30 Min The first player to end their turn with 4 souls is the winner Base Game | The Binding

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They must play loot cards (single-use cards that cause specific effects), fight monsters (which drop rewards such as money or loot cards), and buy items (which grant new abilities) to help them become the first player with four souls (which are usually gained by killing boss monsters or completing bonus objectives)

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