NRX-1933 Size:2mg 03 SMILES C[C@H]1CN(C[C@@H](C)C1(F)F)C1=NC(NC2=CC3=C(C=C2)N(C)C(=O)N3CCC(C)(C)C)=C(Cl)C=N1 Purity (HPLC)

03 SMILES C[C@H]1CN(C[C@@H](C)C1(F)F)C1=NC(NC2=CC3=C(C=C2)N(C)C(=O)N3CCC(C)(C)C)=C(Cl)C=N1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

65 SMILES [2H]C([2H])([2H])N(C1=C(F)C=CC=C1Cl)C([2H])([2H])[2H] Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

354 SMILES OCCOCCNC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mayasundari

Product Name methyl 4-[(2

NRX-1933 Size:2mg 03 SMILES C[C@H]1CN(C[C@@H](C)C1(F)F)C1=NC(NC2=CC3=C(C=C2)N(C)C(=O)N3CCC(C)(C)C)=C(Cl)C=N1 Purity (HPLC)NRX 1933 is an enhancer of the interaction between beta catenin and beta TrCP. NRX 1933 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta catenin by the 26S proteasome. Product Name NRX 1933 Synonyms CAS Number 2763260 30 4 Related CAS Molecular Formula C14H9F3N6O2 Molecular Weight 350. 261 SMILES FC(F)(F)C1=CC=C(C(=O)NC2=CC(=CC=C2)C2=NN=NN2)C(=O)N1 Purity (HPLC) >= 95% Physical Appearance White