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626 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Product Name Mal-Propionyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-MMAE Synonyms CAS Number Related CAS Molecular Formula C83H133N11O24 Molecular Weight 1669
Product Name DOTA-tris(t-Bu)ester-hexyne Synonyms CAS Number n/a Related CAS Molecular Formula C34H61N5O7 Molecular Weight 651
It is also a potent
Product Name Thalidomide-O-C3-acid Synonyms Thalidomide-4'-O-C3-acid CAS Number 2169266-64-0 Related CAS Molecular Formula C17H16N2O7 Molecular Weight 360
Mal-Propionyl-Beta-Ala-Val-Cit-PAB(m-PEG8)-Exatecan Size:25mg 626 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(O)=O)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,
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