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Propargyl-Gly(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan Size:1mg 563 SMILES [N-]=[N+]=NCCOCCOCCOCCOCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

SKU: 43669279923

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Description

563 SMILES [N-]=[N+]=NCCOCCOCCOCCOCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

emission maximum = 578 nm

which can be conjugated to target protein ligands through straightforward chemical reactions

making the linkers highly adaptable for diverse ADC and related applications

Its high reactivity towards HOCl makes NBD-TM the probe of choice for HTS campaigns based on HOCl detection

Propargyl-Gly(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan Size:1mg 563 SMILES [N-]=[N+]=NCCOCCOCCOCCOCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The

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