DBCO-Dap(m-PEG4)-Val-Ala-PAB-PNP Pomalidomide Product Name Lenalidomide-acetamido-O-PEG2-C2-Cl Synonyms Lenalidomide-4'-acetamido-O-PEG2-C2-Cl

Product Name Lenalidomide-acetamido-O-PEG2-C2-Cl Synonyms Lenalidomide-4'-acetamido-O-PEG2-C2-Cl CAS Number n/a Related CAS Molecular Formula C21H26ClN3O7 Molecular Weight 467

55 SMILES [H][C@]12CS[C@@H](CCCCC(=O)NCCOCCOCCOCCC(O)=O)[C@@]1([H])NC(=O)N2 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

93 Purity (HPLC) >= 95% Solubility DMSO

83 SMILES ClCCOCCOCC(=O)NC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

362 SMILES CC(C)(C)OC(=O)CCOCCN1CCNCC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

DBCO-Dap(m-PEG4)-Val-Ala-PAB-PNP Pomalidomide Product Name Lenalidomide-acetamido-O-PEG2-C2-Cl Synonyms Lenalidomide-4'-acetamido-O-PEG2-C2-ClSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG,