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CC-647 is a Cereblon modulator
NRX-252262 is an enhancer of the interaction between beta-catenin and beta-TrCP
solubility
Product Name Phthalimidinoglutarimide-C3-O-PEG2-C2-amine HCl Synonyms Phthalimidinoglutarimide-4'-C3-O-PEG2-C2-amine HCl CAS Number 2138439-22-0 Related CAS Molecular Formula C22H32ClN3O6 Molecular Weight 469
Product Name Pomalidomide-5'-C6-amine HCl Synonyms CAS Number n/a Related CAS 2097509-16-3 (free base) Molecular Formula C19H25ClN4O4 Molecular Weight 408
DBCO-Dap(m-PEG4)-Val-Ala-PAB(m-PEG4)-MMAE dbco-dap-m-PEG4 CC-647 is a Cereblon modulatorSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further
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