A more powerful format tends to have more effective means of drawing cards and churning through a deck, it will do these things more quickly, and it will also tend towards having cheaper cards overall, thus commanding more draw effects so as to keep the tap running
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It can help you hit your land drop when you need it to, and then you can Proliferate in the later game and get some nice value
Once the Sixth Edition rules changes removed that structure, Regenerate shifted into the "shield" version that players know, but probably don't particularly love, today
Grafted Exoskeleton + Phyresis + Tainted Strike Some of the evilest cards in casual Commander tables, but not worthy of getting independent mentions