The ultra-rare Cosmic Foil version of The Soul Stone is already the top chase card in the Spider-Man set, and each future stone will likely receive a similar premium treatment
Its important to note that effects that say each player dont target, so even if a player has protection from everything, cards that say each player sacrifices a creature or each player loses 5 life will still work
You can add in hexproof creatures and play a Voltron- / Bogles-style deck, head toward enchantment creatures like Courser of Kruphix with Kestia, the Cultivator leading the way, or go all-in on comboing off with Estrid, the Masked and The Chain Veil
Once priced at around $2, the regular M20 version of Cavalier of Thorns is now worth around $14
The Frog has a smaller body at 1/1, but it can block flyers with reach and then give it deathtouch with 2 mana so if you have it untapped and ready, people might avoid attacking you with grounded or flying stuff too in order to not trade down with a 2 mana 1/1